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As one of the chief components of the extracellular matrix, it contributes significantly to cell proliferation and migration, and is involved in the progression of many malignant tumors. [ 7 ] [ 8 ] Hyaluronic acid is also a component of the group A streptococcal extracellular capsule , [ 9 ] and is believed to play a role in virulence .
In clinical pharmacology, dose refers to the amount of drug administered to a person, and dosage is a fuller description that includes not only the dose (e.g., "500 mg") but also the frequency and duration of the treatment (e.g., "twice a day for one week").
This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.It is intended as introductory material for novices; for more specific and technical definitions from sub-disciplines and related fields, see Glossary of cell biology, Glossary of genetics, Glossary of evolutionary biology, Glossary of ecology ...
Similarly, when the intravenous infusion is ended, the drug concentration decreases exponentially and reaches an undetectable level after 5–6 half-lives have passed. [ 5 ] [ 6 ] If the same drug is administered as a bolus (medicine) with a single injection, peak concentration is achieved almost immediately and then the concentration declines ...
Still, the blood values are approximately equal between the arterial and venous sides for most substances, with the exception of acid–base, blood gases and drugs (used in therapeutic drug monitoring (TDM) assays). [6] Arterial levels for drugs are generally higher than venous levels because of extraction while passing through tissues. [6]
A dose–response curve is a coordinate graph relating the magnitude of a dose (stimulus) to the response of a biological system. A number of effects (or endpoints) can be studied. The applied dose is generally plotted on the X axis and the response is plotted on the Y axis. In some cases, it is the logarithm of the dose that is plotted on the ...
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Gene dosage is the number of copies of a particular gene present in a genome. [1] Gene dosage is related to the amount of gene product (proteins or functional RNAs) the cell is able to express. Since a gene acts as a template, the number of templates in the cell contributes to the amount of gene product able to be produced.
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