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14602 Ensembl ENSG00000106128 ENSMUSG00000004654 UniProt Q02643 P32082 RefSeq (mRNA) NM_000823 NM_001009824 NM_001003685 RefSeq (protein) NP_000814 NP_001003685 Location (UCSC) Chr 7: 30.94 – 30.99 Mb Chr 6: 55.35 – 55.37 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone ...
GHRH binding to GHRHR results in increased GH production mainly by the cAMP-dependent pathway, [5] but also by the phospholipase C pathway (IP 3 /DAG pathway), [1] and other minor pathways. [ 1 ] The cAMP-dependent pathway is initiated by the binding of GHRH to its receptor, causing receptor conformation that activates G s alpha subunit of the ...
This gene encodes a protein that is a transmembrane receptor for growth hormone. [10] [11] Binding of growth hormone to the receptor leads to reorientation of a pre-assembled receptor dimer dimerization (the receptor may however also exist as monomers on the cell surface [12]) and the activation of an intra- and intercellular signal transduction pathway leading to growth. [13]
One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for ghrelin; however, it may function to attenuate activity of isoform 1a ...
2796 14714 Ensembl ENSG00000147437 ENSMUSG00000015812 UniProt P01148 P13562 RefSeq (mRNA) NM_001083111 NM_000825 NM_008145 RefSeq (protein) NP_000816 NP_001076580 NP_032171 Location (UCSC) Chr 8: 25.42 – 25.42 Mb Chr 14: 67.98 – 67.99 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of ...
The GABA neurotransmitter mediates the fast synaptic inhibition in the central nervous system. When GABA is released from its pre-synaptic cell, it will bind to a receptor (most likely the GABA A receptor) that causes the post-synaptic cell to hyperpolarize (stay below its action potential threshold). This will counteract the effect of any ...
The human ERBB3 gene is located on the long arm of chromosome 12 (12q13). It is encoded by 23,651 base pairs and translates into 1342 amino acids. [5]During human development, ERBB3 is expressed in skin, bone, muscle, nervous system, heart, lungs, and intestinal epithelium. [6]
GnRH neurons, or gonadotropin-releasing hormone expressing neurons, are the cells in the hypothalamic infundibular nucleus in the brain that control the release of reproductive hormones from the pituitary. [1]