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Liver sinusoid. Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves ...
In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue , consisting of a portal triad, hepatocytes arranged in linear cords between a capillary network, and a central vein .
There are three different types of capillaries: continuous, fenestrated, and sinusoidal also called discontinuous. In continuous capillaries the endothelial cells are tightly spaced, allowing only small molecules like ions or water to diffuse through the intercellular clefts (the gaps between the endothelial cells).
A capillary is a small blood vessel, from 5 to 10 micrometres in diameter, and is part of the microcirculation system. Capillaries are microvessels and the smallest blood vessels in the body. They are composed of only the tunica intima (the innermost layer of an artery or vein), consisting of a thin wall of simple squamous endothelial cells. [2]
The cells were first observed by Karl Wilhelm von Kupffer in 1876. [11] The scientist called them "Sternzellen" (star cells or hepatic stellate cell) but thought, inaccurately, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it.
Structure. The liver, viewed from above, showing the left and right lobes separated by the falciform ligament. The liver is a dark reddish brown, wedge-shaped organ with two lobes of unequal size and shape. A human liver normally weighs approximately 1.5 kilograms (3.3 pounds) [11] and has a width of about 15 centimetres (6 inches). [12]
Anatomical terms of microanatomy. [edit on Wikidata] A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: Protein synthesis. Protein storage. Transformation of carbohydrates. Synthesis of cholesterol, bile salts and phospholipids.
Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is a condition of the liver in which the normal functioning tissue, or parenchyma, is replaced with scar tissue (fibrosis) and regenerative nodules as a result of chronic liver disease. [6][7][8] Damage to the liver leads to repair of liver tissue and ...