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Oxygenation zones are numbered inside the diamond-shaped acinus (in red). Zone three is closest to the central vein and zone one is closest to the portal triad. Zones differ by function: zone I hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, β-oxidation of fatty acids and cholesterol synthesis
Anatomical terms of microanatomy. [edit on Wikidata] A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: Protein synthesis. Protein storage. Transformation of carbohydrates. Synthesis of cholesterol, bile salts and phospholipids.
The liver, viewed from above, showing the left and right lobes separated by the falciform ligament. The liver is a dark reddish brown, wedge-shaped organ with two lobes of unequal size and shape. A human liver normally weighs approximately 1.5 kilograms (3.3 pounds) [11] and has a width of about 15 centimetres (6 inches). [12]
Hepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is ...
Mallory body. Micrograph showing a Mallory body with the characteristic twisted-rope appearance (centre of image - within a ballooning hepatocyte). H&E stain. In histopathology, a Mallory body, Mallory–Denk body (MDB), or Mallory's hyaline is an inclusion found in the cytoplasm of liver cells. [1] Mallory bodies are damaged intermediate ...
A liver segment is one of eight segments of the liver as described in the widely used Couinaud classification (named after Claude Couinaud) in the anatomy of the liver.This system divides the lobes of the liver into eight segments based on a transverse plane through the bifurcation of the main portal vein, [1] arranged in a clockwise manner starting from the caudate lobe.
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Liver sinusoid. Sinusoid of a rat liver with fenestrated endothelial cells. Fenestrae are approx 100 nm diameter, and the sinusoidal width 5 µm. A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves ...