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The normal concentration range of uric acid (or hydrogen urate ion) in human blood is 25 to 80 mg/L for men and 15 to 60 mg/L for women [17] (but see below for slightly different values). An individual can have serum values as high as 96 mg/L and not have gout. [18]
Hyperuricaemia or hyperuricemia is an abnormally high level of uric acid in the blood.In the pH conditions of body fluid, uric acid exists largely as urate, the ion form. [1] [2] Serum uric acid concentrations greater than 6 mg/dL for females, 7 mg/dL for males, and 5.5 mg/dL for youth (under 18 years old) are defined as hyperuricemia. [3]
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine.Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury.
Arms and hands of a 50-year-old man, showing large tophi of sodium urate affecting the elbow, knuckles, and finger joints. The crystallization of uric acid, often related to relatively high levels in the blood, is the underlying cause of gout. This can occur because of diet, genetic predisposition, or underexcretion of urate, the salts of uric ...
The combined surface area of all red blood cells of the human body would be roughly 2,000 times as great as the body's exterior surface. [ 14 ] 4,000–11,000 leukocytes : [ 15 ] White blood cells are part of the body's immune system ; they destroy and remove old or aberrant cells and cellular debris, as well as attack infectious agents ...
In 2013, the book was updated and reprinted in two volumes. [citation needed] American Girl published The Care and Keeping of You 1: The Body Book for Younger Girls an edited reprint of the original, and The Care and Keeping of You 2: The Body Book for Older Girls, a sequel intended for older girls.
Ruth B. Bottigheimer catalogued this and other disparities between the 1810 and 1812 versions of the Grimms' fairy tale collections in her book, Grimms' Bad Girls And Bold Boys: The Moral And Social Vision of the Tales. Of the "Rumplestiltskin" switch, she wrote, "although the motifs remain the same, motivations reverse, and the tale no longer ...
A sequel targeted at girls, The Daring Book for Girls, was published in late October 2007. It was written by Andrea J. Buchanan and Miriam Peskowitz. [8] The Dangerous Book for Boys partnered with science kit publisher Thames & Kosmos, who released two kits licensed under The Dangerous Book for Boys in autumn of 2009. [9]