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Tizanidine is a derivative of 2,1,3-benzothiadiazole and its first published synthesis was reported in a patent. [17] The 5-chloro-2,1,3-benzothiadiazol-4-amine intermediate was a known compound, produced in three steps from 4-chlorophenylenediamine as shown. [ 18 ]
However, rheumatologists often prescribe cyclobenzaprine nightly on a daily basis to increase stage 4 sleep. By increasing this sleep stage, patients feel more refreshed in the morning. Improving sleep is also beneficial for patients who have fibromyalgia. [19] Muscle relaxants such as tizanidine are prescribed in the treatment of tension ...
For the first time a new study describes the synchronized oscillations during sleep that power the brain’s glymphatic system to help remove ‘waste’ associated with neurodegenerative diseases ...
From the outset, correcting an iron deficiency may seem small, but it can make a world of a difference in helping you feel empowered and in control of your health. Restoring iron to your body can ...
[medical citation needed] Elucidation of the exact mechanism of action is ongoing but there is limited study due to the existence of more effective, safe muscle relaxants (e.g., diazepam, cyclobenzaprine, tizanidine), greatly limiting the potential benefit of identifying novel compounds which share chlorzoxazone's mechanism of action.
The ideal temperature for sleep is typically between 60°F and 67°F for most adults, says Martina Vendrame, M.D., neurologist and sleep medicine specialist at Lehigh Valley Health Network.
Mayo Clinic Arizona is a multi-campus medical clinic and tertiary medical center in Phoenix, Arizona. Its two main campuses are the outpatient clinic building, situated in east Scottsdale, Arizona, and the Arizona Hospital, located in north Phoenix, Arizona. [ 1 ]
Winter brings less daylight and colder temperatures, which can disrupt sleep. Seasonal Affective Disorder (SAD) is more common in winter due to the lack of sunlight, causing sleep disturbances.