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In August 2020, the U.S. Food and Drug Administration (FDA) became aware of nitrosamine impurities in certain samples of rifampin. [61] The FDA and manufacturers are investigating the origin of these impurities in rifampin, and the agency is developing testing methods for regulators and industry to detect the 1-methyl-4-nitrosopiperazine (MNP ...
A triskelion or triskeles is an ancient motif consisting either of a triple spiral exhibiting rotational symmetry or of other patterns in triplicate that emanate from a common center. The spiral design can be based on interlocking Archimedean spirals , or represent three bent human limbs.
Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.
Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. [2] In active tuberculosis it is used together with other antituberculosis medications. [2]
The partition coefficient (P) of minocycline has been reported to be 39.4 (i.e., log P of 1.60). [72] However, other sources have stated the experimental log P of minocycline to be 0.05, [71] 0.5, [73] and 1.1. [74] In any case, minocycline is consistently described as a highly lipophilic compound with excellent tissue penetration and distribution.
Scientists at the Italian drug company Achifar discovered rifabutin in 1975. (Eventually Archifar became part of Farmitalia Carlo Erba, a unit of the conglomerate Montedison which was subsequently bought by Pharmacia) This company's Adria Laboratories subsidiary filed for Food and Drug Administration (FDA) approval of rifabutin under the brand name Mycobutin in the early 1990s and the drug ...
Hypersensitivity reactions occur in 1.4% of persons treated with dapsone, and can be fatal in medical settings with low resources. [24] [25] It is a form of severe cutaneous adverse reactions (SCARs) in which a SCARs disorder, primarily the DRESS syndrome or a DRESS syndrome-like reaction occurs. [26] [27]
Triskelion (Marvel Cinematic Universe), the headquarters of S.H.I.E.L.D. in the Marvel Cinematic Universe; Triskelion – the fictional ternary starlit world depicted in "The Gamesters of Triskelion" episode of the original Star Trek television series; Triskellion (series) – a series of fictional books written by Mark Billingham and Peter Cocks