Search results
Results from the WOW.Com Content Network
Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution; although, only in a few cases are genes the primary cause of obesity.
Monogenic obesity is excess weight caused by a mutation in a single gene, as opposed to syndromic obesity not tied to a single gene variation and most obesity, which is caused by multiple genetic and environmental risk factors. Monogenetic obesity mostly affects the hypothalamus and leptin–melanocortin system (see hypothalamic obesity ...
Prentice et al. [17] predicted that the emerging molecular genetics field would ultimately provide a way to test between the adaptive 'thrifty gene' idea and the non-adaptive 'drifty gene' idea because it would be possible to find signatures of positive selection in the human genome, at genes that are linked to both obesity and type 2 diabetes ...
In this study, however, we found a clear genetic trigger for obesity,” said lead study author Dr. Mattia Frontini, British Heart Foundation senior fellow and an associate professor in cellular ...
Obesity has been associated with an inflammatory state, which is chronic and low-grade inflammation, known as meta-inflammation. [6] [7] Meta-inflammation is subclinical meaning that while there is an increase in circulating pro-inflammatory factors, no clinical signs of inflammation, heat, pain, and redness, are seen with meta-inflammation. [8]
Heredity, also called inheritance or biological inheritance, is the passing on of traits from parents to their offspring; either through asexual reproduction or sexual reproduction, the offspring cells or organisms acquire the genetic information of their parents.
As such, obesity is a major feature of a number of rare genetic conditions that often present in childhood: Prader–Willi syndrome , with an incidence between 1 in 12,000 and 1 in 15,000 live births, is characterized by hyperphagia and food preoccupations which leads to rapid weight gain in those affected.
Obesity is a major cause of disability and is correlated with various diseases and conditions, particularly cardiovascular diseases, type 2 diabetes, obstructive sleep apnea, certain types of cancer, and osteoarthritis. [2] [12] [13] Obesity has individual, socioeconomic, and environmental causes.