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Lenalidomide. Lenalidomide, sold under the brand name Revlimid among others, is a medication used to treat multiple myeloma, smoldering myeloma, and myelodysplastic syndromes (MDS). [8] For multiple myeloma, it is a first line treatment, and is given with dexamethasone. [8] It is taken by mouth. [8]
Cereblon E3 ligase modulators, also known as immunomodulatory imide drugs ( IMiDs ), are a class of immunomodulatory drugs [1] (drugs that adjust immune responses) containing an imide group. The IMiD class includes thalidomide and its analogues ( lenalidomide, pomalidomide, mezigdomide and iberdomide ). [1] These drugs may also be referred to ...
The preferred treatment for those under the age of 65 is high-dose chemotherapy, commonly with bortezomib-based regimens, and lenalidomide–dexamethasone, to be followed by a stem cell transplant. A 2016 study concluded that stem cell transplant is the preferred treatment of multiple myeloma.
In 2014, according to the World Marrow Donor Association, stem-cell products provided for unrelated transplantation worldwide had increased to 20,604 (4,149 bone-marrow donations, 12,506 peripheral blood stem-cell donations, and 3,949 cord-blood units). Graft types Autologous
Peripheral blood stem cell transplantation (PBSCT), also called "Peripheral stem cell support", is a method of replacing blood-forming stem cells.Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as leukemia, lymphoma, neuroblastoma and multiple myeloma.
Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers ( e.g., multiple myeloma ), graft-versus-host disease, and many skin disorders ( e.g., complications of leprosy such as skin lesions ). [6] [7] [8] Thalidomide has been used to treat conditions associated with HIV ...
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