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Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic arterial hypoperfusion to the eye. [1] Amaurosis fugax is a form of acute vision loss caused by reduced blood flow to the eye; it may be a warning sign of an impending stroke, as both stroke and retinal artery occlusion can be caused by thromboembolism due to atherosclerosis elsewhere in the ...
The optic nerve can be at very high risk for damage from insufficient blood supply due to swelling (from lack of oxygen) in a confined bony space resulting in a compartment syndrome. Restricted blood flow can lead to permanent damage to the optic nerve and result in blindness (often in both eyes).
Other factors can cause glaucoma, known as "secondary glaucoma", including prolonged use of steroids (steroid-induced glaucoma); conditions that severely restrict blood flow to the eye, such as severe diabetic retinopathy and central retinal vein occlusion (neovascular glaucoma); ocular trauma (angle-recession glaucoma); plateau iris; and ...
Temporary vasospasm leading to decreased blood flow can be a cause of amaurosis fugax. [14] [15] Generally, these episodes are brief, lasting no longer than five minutes, [16] and have been associated with exercise. [10] [17] These vasospastic episodes are not restricted to young and healthy individuals. "Observations suggest that a systemic ...
Sleep apnea is a condition characterized by repeated interruptions in breathing during sleep, significantly affecting the flow of blood through the brain's blood vessels. These interruptions cause intermittent hypoxia, leading to vascular changes such as the constriction of cerebral blood vessels, thereby impacting overall brain blood flow.
Ischemia or ischaemia is a restriction in blood supply to any tissue, muscle group, or organ of the body, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). [ 3 ] [ 4 ] Ischemia is generally caused by problems with blood vessels , with resultant damage to or dysfunction of tissue, i.e., hypoxia and ...
Pentoxifylline has been shown to reduce erythrocyte rigidity, resulting in decreased blood viscosity and increased flow velocity. [23] Animal studies have demonstrated that pentoxifylline can inhibit TNF and, in turn, prevent retinal ganglion cell death and axonal degeneration associated with optic neuropathy in a dose-dependent manner.
In ischemic optic neuropathies, there is insufficient blood flow (ischemia) to the optic nerve. The anterior optic nerve is supplied by the short posterior ciliary artery and choroidal circulation, while the retrobulbar optic nerve is supplied intraorbitally by a pial plexus, which arises from the ophthalmic artery, internal carotid artery ...