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The area under the effect curve (AUEC) is an integral of the effect of a drug over time, estimated as a previously-established function of concentration. It was proposed to be used instead of AUC in animal-to-human dose translation, as computer simulation shows that it could cope better with half-life and dosing schedule variations than AUC.
However, toxicity from treatment was variable, and therefore Professor Hillary Calvert (University of Newcastle) developed a formula to dose carboplatin based on renal function. Calvert's formula considers the creatinine clearance and the desired area under curve. [13] After 24 hours, close to 70% of carboplatin is excreted in the urine unchanged.
The absolute bioavailability is the dose-corrected area under curve (AUC) non-intravenous divided by AUC intravenous. The formula for calculating the absolute bioavailability, F, of a drug administered orally (po) is given below (where D is dose administered).
Pages for logged out editors learn more. Contributions; Talk; Area-under-curve (pharmacokinetics)
The main criticism to the ROC curve described in these studies regards the incorporation of areas with low sensitivity and low specificity (both lower than 0.5) for the calculation of the total area under the curve (AUC)., [19] as described in the plot on the right.
C max is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administered and before the administration of a second dose. [1] It is a standard measurement in pharmacokinetics.
The term "quadrature" is a traditional term for area; the integral is geometrically interpreted as the area under the curve y = x n. Traditionally important cases are y = x 2 , the quadrature of the parabola , known in antiquity, and y = 1/ x , the quadrature of the hyperbola , whose value is a logarithm .
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