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Urea cycle. The urea cycle (also known as the ornithine cycle) is a cycle of biochemical reactions that produces urea (NH 2) 2 CO from ammonia (NH 3). Animals that use this cycle, mainly amphibians and mammals, are called ureotelic. The urea cycle converts highly toxic ammonia to urea for excretion. [1] This cycle was the first metabolic cycle ...
Hyperammonemia. Due to accumulation of argininosuccinate, citrulline, and arginine in the liver when the urea cycle is deficient. Hyperammonemia, or high ammonia levels, is a metabolic disturbance characterised by an excess of ammonia in the blood. It is a dangerous condition that may lead to brain injury and death. It may be primary or secondary.
Ammonia is both a metabolic waste and a metabolic input throughout the biosphere. It is an important source of nitrogen for living systems. It is an important source of nitrogen for living systems. Although atmospheric nitrogen abounds (more than 75%), few living creatures are capable of using atmospheric nitrogen in its diatomic form, N 2 gas.
Urine is a liquid by-product of metabolism in humans and in many other animals. In placental mammals, urine flows from the kidneys through the ureters to the urinary bladder and is ejected from the penis or vulva through the urethra during urination. In other vertebrates, urine is excreted through the cloaca. [1]
Excretory system. The excretory system is a passive biological system that removes excess, unnecessary materials from the body fluids of an organism, so as to help maintain internal chemical homeostasis and prevent damage to the body. The dual function of excretory systems is the elimination of the waste products of metabolism and to drain the ...
Carbohydrate metabolism is the whole of the biochemical processes responsible for the metabolic formation, breakdown, and interconversion of carbohydrates in living organisms. Carbohydrates are central to many essential metabolic pathways. [1] Plants synthesize carbohydrates from carbon dioxide and water through photosynthesis, allowing them to ...
Ornithine transcarbamylase, the defective enzyme in this disorder, is the final enzyme in the proximal portion of the urea cycle, responsible for converting carbamoyl phosphate and ornithine into citrulline. OTC deficiency is inherited in an X-linked recessive manner, meaning males are more commonly affected than females.
Protein toxicity is the effect of the buildup of protein metabolic waste compounds, like urea, uric acid, ammonia, and creatinine. Protein toxicity has many causes, including urea cycle disorders, genetic mutations, excessive protein intake, and insufficient kidney function, such as chronic kidney disease and acute kidney injury. [1][2][3][4 ...