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Lutetium (177 Lu) oxodotreotide or 177 Lu dotatate, brand name Lutathera, is a chelated complex of a radioisotope of the element lutetium with dotatate, used in peptide receptor radionuclide therapy. Specifically, it is used in the treatment of cancers which express somatostatin receptors. [5] It is a radiolabeled somatostatin analog. [3] [6] [7]
DOTA-TATE can be reacted with the radionuclides gallium-68 (T 1/2 = 68 min), lutetium-177 (T 1/2 = 6.65 d) and copper-64 (T 1/2 = 12.7 h) to form radiopharmaceuticals for positron emission tomography (PET) imaging or radionuclide therapy. 177 Lu DOTA-TATE therapy is a form of peptide receptor radionuclide therapy (PRRT) which targets ...
177 Lu-DOTATATE was associated with limited acute toxic effects. In neuroendocrine tumor patients with advanced well-differentiated disease and progression on somatostatin analogs, 177 Lu-DOTATATE is likely to reduce the risk of disease progression and be associated with quality-of-life benefits. [19] [20]
Lutetium (177 Lu) chloride is a radioactive compound used for the radiolabeling of pharmaceutical molecules, aimed either as an anti-cancer therapy or for scintigraphy (medical imaging). [ 5 ] [ 6 ] It is an isotopomer of lutetium(III) chloride containing the radioisotope 177 Lu , which beta decays with a half-life of 6.64 days.
Lutetium-177 labelled edotreotide (177 Lu-DOTA-TOC), with the trade name Solucin, is the subject of a phase 3 clinical trial for treatment of GEP-NETs. [ 7 ] [ 8 ] It was granted orphan drug designation by the European Medicines Agency in 2014.
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Attached to the dotatate is the radioactive marker Lu-177, a radioisotope. [16] The dotatate binds to the GEP-NET positive somatostatin receptor cells commonly present on neuroendocrine tumors. [16] [20] After binding to the receptor, Lutathera enters the cell and uses its radioactive property to damage DNA. [16]
The approved copies identified by the Reuters review tend to be much cheaper than the originals. In Russia, for example, a month's supply of Semavic, used for diabetes and containing semaglutide ...