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Dentatorubral–pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar degeneration caused by an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein. [1] It is also known as Haw River syndrome and Naito–Oyanagi disease. Although this condition was perhaps first described by Smith et al. in 1958 ...
This is the case for Huntington's disease, where the trinucleotide repeat encodes a long stretch of glutamine residues. When the repeat is present in an untranslated region, it could affect the expression of the gene in which the repeat is found (ex. fragile X ) or many genes through a dominant negative effect (ex. myotonic dystrophy ).
The carrying capacity is defined as the environment's maximal load, [clarification needed] which in population ecology corresponds to the population equilibrium, when the number of deaths in a population equals the number of births (as well as immigration and emigration). Carrying capacity of the environment implies that the resources ...
The first principle of population dynamics is widely regarded as the exponential law of Malthus, as modelled by the Malthusian growth model.The early period was dominated by demographic studies such as the work of Benjamin Gompertz and Pierre François Verhulst in the early 19th century, who refined and adjusted the Malthusian demographic model.
His iconic diagram of the numbers of marine families from the Cambrian to the Recent illustrates the successive expansion and dwindling of three "evolutionary faunas" that were characterized by differences in origination rates and carrying capacities. Long-term ecological changes and major geological events are postulated to have played crucial ...
A sharp reduction in the average size of many organisms, likely attributable to the Lilliput effect, and the disappearance of many relict taxa from the Ordovician indicate a third extinction interval linked to an expansion of anoxic conditions into shallower shelf environments, particularly in Baltica. This sharp decline in dissolved oxygen ...
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The certification applies to somatic death, corresponding to death of the person, which has varying definitions but most commonly describes a lack of vital signs and brain function. [9] Death at the level of cells, called molecular death or cell death , follows a matter of hours later. [ 10 ]