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Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group.
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. [3] It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle . Physical properties
Several different ingredients can be used to form the base of a suppository: cocoa butter or a similar substitute, polyethylene glycol, hydrogels, and glycerinated gelatin. The type of material used depends on the type of suppository, the type of drug, and the conditions in which the suppository will be stored. [4]
Antioxidants are used to prevent gel ingredients from being oxidised. [3] When choosing the antioxidant to be used, it is important to consider the nature of the solvent. [ 3 ] Since the solvent of most gels are aqueous in nature, water-soluble antioxidants are more commonly used. [ 3 ]
A container with cream. Topical cream formulation is an emulsion semisolid dosage form that is used for skin external application. Most of the topical cream formulations contain more than 20 per cent of water and volatiles and/or less than 50 per cent of hydrocarbons, waxes, or polyethylene glycols as the vehicle for external skin application. [1]
Ingredient names must comply by law with EU requirements by using INCI names. [8] The cosmetic regulation laws are enforceable for important consumer safety. For example, the ingredients are listed on the ingredient declaration for the purchaser to reduce the risk of an allergic reaction to an ingredient the user has had an allergy to before.
The active ingredient in Anusol ointment and suppositories is zinc sulfate monohydrate which helps decrease the irritation in the area and acts as an astringent.The active ingredient in Anusol plus is zinc sulfate monohydrate and pramoxine HCL, which is antipruritic (also found in Gold Bond). [1]
Active ingredients are broken up in both cycles depending on the raw materials involved and the desired properties of the lotion or cream. A typical oil-in-water manufacturing process may be: Step 1: Add flake/powder ingredients to the oil being used to prepare the oil phase. Step 2: Disperse active ingredients.