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Peroxisomal membrane proteins are imported through at least two routes, one of which depends on interaction between peroxin 19 and peroxin 3, while the other is required for import of peroxin 3, either of which may occur without the import of matrix (lumen) enzymes, which possess the peroxisomal targeting signal PTS1 or PTS2 as previously ...
Deficiencies are associated with several peroxisomal disorders. Peroxins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome.
In particular, this enzyme contributes to breaking the double bonds at all even-numbered positions, and some double bonds at odd-numbered position. [8] The structure of the ternary complex of pDCR (peroxisomal 2,4-dienoyl CoA reductases) with NADP and its substrate provides essential and unique insights into the mechanism of catalysis. [15]
Peroxisomal acyl-coenzyme A oxidase 1 is an enzyme that in humans is encoded by the ACOX1 gene. [5] [6]The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs.
55825 111175 Ensembl ENSG00000115425 ENSMUSG00000026189 UniProt Q9BY49 Q99MZ7 RefSeq (mRNA) NM_018441 NM_023523 NM_001356516 RefSeq (protein) NP_060911 NP_076012 NP_001343445 Location (UCSC) Chr 2: 216 – 216.08 Mb Chr 1: 72.3 – 72.32 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal trans-2-enoyl-CoA reductase is an enzyme that in humans is encoded by the PECR gene ...
D-bifunctional protein (DBP), also known as peroxisomal multifunctional enzyme type 2 (MFP-2), as well as 17β-hydroxysteroid dehydrogenase type IV (17β-HSD type IV) is a protein that in humans is encoded by the HSD17B4 gene.
The NH-containing residues have been identified as Ala70 and Leu126 and the glutamate as Glu158 in peroxisomal enzymes in a yeast species, Saccharomyces cerevisiae. Their relative locations on the enzyme can be compared in figure 2. [4] The enzymes of the hydratase/isomerase or crotonase superfamily are typically trimeric disks dimerized into ...
2-Hydroxyphytanoyl-CoA lyase is a peroxisomal enzyme involved in the catabolism of phytanoic acid by α-oxidation. It requires thiamine diphosphate (ThDP) as cofactor. [1] It is classified under EC number 4.1.