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The Rumack–Matthew nomogram, also known as the acetaminophen nomogram, is an acetaminophen toxicity nomogram. It plots serum concentration of acetaminophen against the time since ingestion, in order to predict possible liver toxicity and allow a clinician to decide whether to proceed with N-Acetylcysteine (NAC) treatment.
Acute paracetamol overdose in children rarely causes illness or death, and it is very uncommon for children to have levels that require treatment, with chronic larger-than-normal doses being the major cause of toxicity in children. [20] Intentional overdosing (self-poisoning, with suicidal intent) is frequently implicated in paracetamol ...
NAPQI, also known as NAPBQI or N-acetyl-p-benzoquinone imine, is a toxic byproduct produced during the xenobiotic metabolism of the analgesic paracetamol (acetaminophen). [1] It is normally produced only in small amounts, and then almost immediately detoxified in the liver.
In the treatment of paracetamol (acetaminophen) overdose, acetylcysteine acts to maintain or replenish depleted glutathione reserves in the liver and enhance non-toxic metabolism of acetaminophen. [23] These actions serve to protect liver cells from NAPQI toxicity.
Syrup of ipecac (/ ˈ ɪ p ɪ k æ k /), or simply ipecac, is a drug that was once widely used as an expectorant (in low doses) and a rapid-acting emetic (in higher doses). It is obtained from the dried rhizome and roots of the ipecacuanha plant (Carapichea ipecacuanha), from which it derives its name.
US CDC warns of overdose risk from fake prescription medicines online. October 2, 2024 at 5:37 PM (Reuters) - The U.S. Centers for Disease Control and Prevention on Wednesday alerted public health ...
Paracetomol (3D structure) overdose is the most common cause of drug-induced liver disease. Paracetamol also known as acetaminophen, and by the brand names of Tylenol and Panadol, is usually well-tolerated in prescribed dose, but overdose is the most common cause of drug-induced liver disease and acute liver failure worldwide. [12]
Negative values of the decimal logarithm of the median lethal dose LD 50 (−log 10 (LD 50)) on a linearized toxicity scale encompassing 11 orders of magnitude. Water occupies the lowest toxicity position (1) while the toxicity scale is dominated by the botulinum toxin (12). [107] The LD 50 values have a very wide range.