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Tizanidine is a derivative of 2,1,3-benzothiadiazole and its first published synthesis was reported in a patent. [17] The 5-chloro-2,1,3-benzothiadiazol-4-amine intermediate was a known compound, produced in three steps from 4-chlorophenylenediamine as shown. [ 18 ]
Muscle relaxants such as tizanidine are prescribed in the treatment of tension headaches. [20] Diazepam and carisoprodol are not recommended for older adults, pregnant women, or people who have depression or for those with a history of drug or alcohol addiction. [21]
Side effects of thiocolchicoside can include nausea, allergy and vasovagal reactions. [15] Liver injury, pancreatitis, seizures, blood cell disorders, severe cutaneous disorders, rhabdomyolysis, and reproductive disorders have all been recorded in the French and European pharmacovigilance databases and in the periodic updates that the companies concerned submit to regulatory agencies.
It can also be administered for acute pain in general and for tension headache (muscle contraction headache). It acts on the spinal cord by depressing reflexes. It is sold under the brand names Lorzone , Paraflex and Muscol and in combination form as Parafon Forte , a combination of chlorzoxazone and acetaminophen (paracetamol).
Cyclobenzaprine results in increased rates of drowsiness (38%), dry mouth (24%), and dizziness (10%). [15] Drowsiness and dry mouth appear to intensify with increasing dose. [20] The sedative effects of cyclobenzaprine are likely due to its antagonistic effect on histamine, serotonin, and muscarinic receptors. [medical citation needed]
I can tell you today, if it isn't widely known yet, that this drug is showing up on the black market, as a would-be Xanax. So all the facts are needed. The article on Quetiapine (Seroquel) is an excellent example! I wouldn't have believed anybody, even in prison, takes an antipsychotic recreationally, if I hadn't read it there.
Orphenadrine (sold under many brand names) [1] is an anticholinergic drug of the ethanolamine antihistamine class; it is closely related to diphenhydramine.It is a muscle relaxant that is used to treat muscle pain and to help with motor control in Parkinson's disease, but has largely been superseded by newer drugs.
Baclofen [65] or tizanidine are sometimes used as an alternative to benzodiazepines. Tizanidine has been found to have superior tolerability compared to diazepam and baclofen. [66] Benzodiazepines are also used to treat the acute panic caused by hallucinogen intoxication. [67]