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This trend continues postnatally along an axis of increased growth from the head to the feet. Finally, in adults, the head represents approximately 12% of the body length. The cephalocaudal trend is also the trend of infants learning to use their upper limbs before their lower limbs. The proximodistal trend, on the other hand, is the prenatal ...
The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA ( DNA replication ) and some of its organelles , and subsequently the partitioning of its cytoplasm, chromosomes and other ...
The cell cycle is a series of complex, ordered, sequential events that control how a single cell divides into two cells, and involves several different phases. The phases include the G1 and G2 phases, DNA replication or S phase, and the actual process of cell division, mitosis or M phase. [ 1 ]
The main mechanism of action of the cell cycle checkpoints is through the regulation of the activities of a family of protein kinases known as the cyclin-dependent kinases (CDKs), which bind to different classes of regulator proteins known as cyclins, with specific cyclin-CDK complexes being formed and activated at different phases of the cell ...
Cells with a defective G 2-M checkpoint will undergo apoptosis or death after cell division if they enter the M phase before repairing their DNA. [1] The defining biochemical feature of this checkpoint is the activation of M-phase cyclin-CDK complexes, which phosphorylate proteins that promote spindle assembly and bring the cell to metaphase. [2]
Each cell type is defined by its particular pattern of regulated gene expression. Cell differentiation is thus a transition of a cell from one cell type to another and it involves a switch from one pattern of gene expression to another. Cellular differentiation during development can be understood as the result of a gene regulatory network.
Also, understanding the cell cycle in individual diseased cells, like those in a tumor, is also important, since they will often have a very different cycle than healthy cells. Single-cell analysis of characteristics of the cell cycle allow scientists to understand these properties in greater detail.
Only this pattern of attachment will ensure that each daughter cell receives one copy of the chromosome. The defining biochemical feature of this checkpoint is the stimulation of the anaphase-promoting complex by M-phase cyclin-CDK complexes , which in turn causes the proteolytic destruction of cyclins and proteins that hold the sister ...