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The tendency of the arteries and veins to stretch in response to pressure has a large effect on perfusion and blood pressure. This physically means that blood vessels with a higher compliance deform easier than lower compliance blood vessels under the same pressure and volume conditions. [ 1 ]
Static lung compliance is the change in volume for any given applied pressure. [1] Dynamic lung compliance is the compliance of the lung at any given time during actual movement of air. Low compliance indicates a stiff lung (one with high elastic recoil) and can be thought of as a thick balloon – this is the case often seen in fibrosis.
Consequently the vessels wall are more stretched so the caliber of the vessels increases causing an increase in flow due to lower resistance. Zone 4 can be seen at the lung bases at low lung volumes or in pulmonary edema. Pulmonary interstitial pressure (Pi) rises as lung volume decreases due to reduced radial tethering of the lung parenchyma ...
The design of a complex pressure containment system involves much more than the application of Barlow's formula. For example, in 100 countries the ASME BPVCcode stipulates the requirements for design and testing of pressure vessels.
For the thin-walled assumption to be valid, the vessel must have a wall thickness of no more than about one-tenth (often cited as Diameter / t > 20) of its radius. [4] This allows for treating the wall as a surface, and subsequently using the Young–Laplace equation for estimating the hoop stress created by an internal pressure on a thin-walled cylindrical pressure vessel:
As the vessels decrease in size, they increase their surface-area-to-volume ratio. This allows surface properties to play a significant role in the function of the vessel. Diffusion occurs through the walls of the vessels due to a concentration gradient, allowing the necessary exchange of ions, molecules, or blood cells.
The increased lung pressure pushes the air out of the lungs. [2] The primary function of ventilation is the replacement of the stale gases in the lungs with oxygen-rich air through the removal of carbon dioxide for oxygenation of the blood. [5] The oxygen is then supplied to the entire body through the circulatory system.
The alveolar pressure is estimated by measuring the pressure in the airways while holding one's breath. [2] The intrapleural pressure is estimated by measuring the pressure inside a balloon placed in the esophagus. [2] Measurement of transpulmonary pressure assists in spirometry in availing for calculation of static lung compliance.