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In 1986 Axel Ullrich, a German scientist working at Genentech, first discovered the Her-2 protein and gave a conference about it in which Slamon was present.Afterwards Slamon proposed to work together, since he suspected that a mutation in Her-2 might cause cancer, eventually they found a kind of aggressive breast cancer with a mutation in the gene responsible for the Her-2 protein and started ...
ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of differentiation 340). [5] [6] [7] HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family ...
Teleplay writer Vivienne Radkoff had the story for about seven years before it was completed. It is an adaptation of Robert Bazell's book HER-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer. The film was the first mainstream feature film to be scored as a solo project by composer Halli Cauthery.
YouTube Movies & TV is a video on demand service that offers movies and television shows for purchase or rental, depending on availability, along with a selection of movies (encompassing between 100 and 500 titles overall) that are free to stream, with interspersed ad breaks. YouTube began offering free-to-view movie titles to its users in ...
Investigation Discovery (ID) is a channel dedicated to true crime documentaries that launched in 2008. Most of ID's programs are original productions. It also airs re-titled off-network reruns, including ABC's 20/20, CBS's 48 Hours, and NBC's Dateline.
The HER2 gene (also known as HER2/neu and ErbB2 gene) is amplified in 20–30% of early-stage breast cancers. [43] Trastuzumab is a monoclonal antibody targeting HER2, inducing an immune-mediated response that causes internalization and recycling of HER2. It may also upregulate cell cycle inhibitors such as p21 Waf1 and p27 Kip1. [57]
Discovered in a La Paz basement in 1989, it required over a decade of restoration and was not released until 2010. [210] 1931: Love and Duty: Bu Wancang: Ruan Lingyu: Silent film made in China, and rediscovered in Uruguay in the 1990s. [211] 1938: As the Earth Turns: Richard Lyford: Discovered over 80 years later in Lyford's former home. [212 ...
Re-narrated Horizon episode, first aired in the UK in 1972. [4]We give you a behind-the-scenes look at the making of a nature film. Oxford Scientific Films Unit shows how it tackles such problems as filming a wood wasp laying its eggs inside trees, the hatching of a chick and the courtship rituals of the stickleback.