Search results
Results from the WOW.Com Content Network
Docusate is the common chemical and pharmaceutical name of the anion bis(2-ethylhexyl) sulfosuccinate, also commonly called dioctyl sulfosuccinate (DOSS). [2] [3] [4]Salts of this anion, especially docusate sodium, are widely used in medicine as an emollient laxative and as stool softeners, by mouth or rectally. [1]
Citalopram, sold under the brand name Celexa among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [7] [10] It is used to treat major depressive disorder, obsessive compulsive disorder, panic disorder, and social phobia. [7]
Antidepressant treatment tachyphylaxis (ADT tachyphylaxis), also known as Prozac poop-out, is a medical condition in which progressive or acute tolerance effects are seen following chronic administration of a drug. [1] It occurs more often with Selective serotonin reuptake inhibitors (SSRIs), which are the most commonly prescribed antidepressants.
Intimate side effects like ED are known to occur with many antidepressants, including the following common medications: Citalopram (generic for Celexa) Sertraline (Zoloft)
More serious side effects may include suicidal thoughts in people up to the age of 24 years. [9] It is unclear if use during pregnancy or breastfeeding is safe. [ 10 ] Escitalopram is the ( S )- enantiomer of citalopram (which exists as a racemate ), hence the name es -citalopram.
Andersen et al. were able to generate a model of the (S)-citalopram binding site in human SERT by combining mutational analysis and comparative modeling where they found out that Asn-177 and Phe-341 where key determinants for (S)-citalopram potency and high affinity inhibition [47] in addition to Tyr-95, Asp-98, Ile-172 and Ser438 previously ...
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 83 ] [ 85 ] [ 86 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 83 ]
Clinical research suggests that SSRIs may have a biphasic response, with research suggesting that citalopram may have immediate anxiogenic effects from one dosage but long-term anxiolytic effects after three dosages in mice, [14] supporting clinical findings of exacerbated anxiety preceding the beneficial effects from SSRIs.