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  2. Hypothalamic–pituitary–adrenal axis - Wikipedia

    en.wikipedia.org/wiki/Hypothalamicpituitary...

    Schematic of the HPA axis (CRH, corticotropin-releasing hormone; ACTH, adrenocorticotropic hormone) Hypothalamus, pituitary gland, and adrenal cortex The hypothalamic–pituitaryadrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus (a part of the brain located below the thalamus), the pituitary gland (a ...

  3. Sympathoadrenal system - Wikipedia

    en.wikipedia.org/wiki/Sympathoadrenal_system

    Increased secretion of catecholamines are a hormone response regulated by the sympathoadrenal system (SAS) and the hypothalamic-pituitary-adrenal axis (HPAA). [10] The "fight or flight" response causes the secretion of hormones such as cortisol and adrenaline which stimulate additional physiological needs to increase respiratory, cardiac ...

  4. Epigenetics of anxiety and stress–related disorders - Wikipedia

    en.wikipedia.org/wiki/Epigenetics_of_anxiety_and...

    These epigenetic modifications, specifically DNA methylation can lead to the phenotypic expression of mental disorders. [40] Changes to the HPA Axis Due to Childhood Trauma. Hypothalamic-pituatary-adrenal (HPA) axis is essential component of the neuroendocrine system that regulates stress response. Persistent dysregulation of the stress ...

  5. Amygdala hijack - Wikipedia

    en.wikipedia.org/wiki/Amygdala_hijack

    If the amygdala perceives a match to the stimulus, i.e., if the record of experiences in the hippocampus tells the amygdala that it is a fight, flight or freeze situation, then the amygdala triggers the HPA (hypothalamic–pituitaryadrenal) axis and "hijacks" or overtakes rational brain function. [5]

  6. Neuroendocrinology - Wikipedia

    en.wikipedia.org/wiki/Neuroendocrinology

    Hypothalamic interaction with the posterior and anterior pituitary glands. The hypothalamus produces the hormones oxytocin and vasopressin in its endocrine cells (left). These are released at nerve endings in the posterior pituitary gland and then secreted into the systemic circulation.

  7. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

    en.wikipedia.org/wiki/Congenital_adrenal...

    [128] [129] Dexamethasone has glucocorticoid activity, and potent ACTH-suppression properties within the hypothalamic–pituitaryadrenal axis. [130] [131] Lower ACTH leads to reduced production of all the steroids, including androgens.

  8. Psychoneuroimmunology - Wikipedia

    en.wikipedia.org/wiki/Psychoneuroimmunology

    Two major pathways are involved in this cross-talk: the Hypothalamic-pituitary-adrenal axis (HPA axis), and the sympathetic nervous system (SNS), via the sympathetic-adrenal-medullary axis (SAM axis). The activation of SNS during an immune response might be aimed to localize the inflammatory response. The body's primary stress management system ...

  9. Hypothalamic disease - Wikipedia

    en.wikipedia.org/wiki/Hypothalamic_disease

    Many of these hypothalamic hormones act on the pituitary gland. Hypothalamic disease therefore affects the functioning of the pituitary and the target organs controlled by the pituitary, including the adrenal glands, ovaries and testes, and the thyroid gland. [2] Numerous dysfunctions manifest as a result of hypothalamic disease.

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