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Alisertib (MLN8237) is an orally available , investigational, reversible, ATP-competitive, selective aurora A kinase inhibitor developed by Takeda. [1] Inhibition of aurora A kinase A leads to disruption of mitotic spindle apparatus assembly, disruption of chromosome segregation, and inhibition of cell proliferation.
A cobalt(III) complex of aminomethyl is known in the form [Co 2 (CH 2 NH 2)](ClO4) 2. [1] Aminomethyl is the first member of a series of 1-aminoalkyl groups of the form −(CH 2 −) n NH 2. [2] Aminomethyl is used in the standard names of some compounds, [3] such as 4-(aminomethyl) benzoic acid.
Lorazepam can be made using 2-amino-2′,5-dichlorobenzophenone (a derivative of 2-amino-5-chlorobenzophenone), which is first reacted with hydroxylamine, the obtained product is then reacted with chloroacetyl chloride to give 6-chloro-2-chlormethyl-4-(2′-chlorophenyl)quinazolin-3-oxide, a reaction with methylamine produces ring expansion and rearrangement, which forms 7-chloro-2-methylamino ...
Anisic acid or methoxybenzoic acid is an organic compound which is a carboxylic acid. It exists in three forms, depending on arene substitution patterns: p-Anisic acid (4-methoxybenzoic acid) m-Anisic acid (3-methoxybenzoic acid) o-Anisic acid (2-methoxybenzoic acid)
4-Aminobenzoic acid (also known as para-aminobenzoic acid or PABA because the two functional groups are attached to the benzene ring across from one another in the para position) is an organic compound with the formula H 2 NC 6 H 4 CO 2 H. PABA is a white crystalline solid, [3] although commercial samples can appear gray. It is slightly soluble ...
It can be prepared by nitration of benzoic acid. It also can be prepared by treating benzaldehyde under nitration conditions, a process that initially converts the aldehyde to the acid. 4-Nitrobenzoic acid is a precursor to 4-aminobenzoic acid, which is in turn used to prepare the anesthetic procaine. 4-Nitrobenzoic acid is prepared by ...
p-Anisic acid, also known as 4-methoxybenzoic acid or draconic acid, is one of the isomers of anisic acid. The term "anisic acid" often refers to this form specifically. [ 1 ] It is a white crystalline solid which is insoluble in water, highly soluble in alcohols, and soluble in ether and ethyl acetate .
Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. [3] [4] Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.