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Inflammatory myofibroblastic tumor was initially regarded as a benign tumor that most often developed in the lung and less commonly in almost any organ system or tissue. Over time, however, IMT cases occurred in which the tumor spread into local tissues, metastasized to distal tissues, recurred after treatment, or consisted of neoplastic cells ...
Desmoid-type fibromatosis, also termed desmoid tumor and aggressive fibromatosis [26] Lipofibromatosis, a mixture of lipofibromatosis tumors with different gene abnormalities; [27] these tumors differ from lipofibromatosis-like neural tumors which have not been classified as fibroblastic and myofibroblastic tumors. Giant cell fibroblastoma [28]
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) might share several aspects of the XP. Likewise there might be some superimpositions between the XP and the plasma cell granuloma/histiocytoma-inflammatory myofibroblastic tumor complex. [18] [19] The XP might be an important stage of this complex.
Acral myxoinflammatory fibroblastic sarcoma (AMSF), also termed myxoinflammatory fibroblastic sarcoma (MSF), is a rare, low-grade, soft tissue tumor that the World Health Organization (2020) classified as in the category of rarely metastasizing fibroblastic and myofibroblastic tumors. [1]
NF may resemble and therefore be misdiagnosed as dermatofibrosarcoma protuberans, fibrosarcoma, malignant fibrous histiocytoma, spindle-cell melanoma, [27] leiomyosarcoma, [4] or inflammatory myofibroblastic tumor. [8] The diagnosis of NF and its variants depends on a combination of findings, no single one of which is definitive.
In 2020, the World Health Organization reclassified MFS as a separate and distinct tumor [4] in the category of malignant fibroblastic and myofibroblastic tumors. [5] MFS tumors are often treated by surgical resection. However, these tumors have high recurrence rates at the sites of their resections. [6]
IMF tumors are usually painless, well-encapsulated, rubbery to hard, and freely movable-to-fixed masses. [8] They may be evident at birth in up to 60% of cases [4] but generally go undetected until they [9] are diagnosed in the first year of life, [8] uncommonly in older infants and young (<10 years/old) children, [4] or rarely in older children and adults (one individual was diagnosed with ...
A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines.