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Elephantiasis, often incorrectly called elephantitis, is the enlargement and hardening of limbs or body parts due to tissue swelling . [ 1 ] [ 2 ] It is characterised by edema, hypertrophy , and fibrosis of skin and subcutaneous tissues, due to obstruction of lymphatic vessels ( lymphedema ). [ 2 ]
Esthiomene is a medical term referring to elephantiasis of the female genitals. [1] [2] In the past, the term has also referred to elephantiasis of the male genitalia. [3] Esthiomene is generally the visible result of lymphogranuloma venereum, lymphatic infection by Chlamydia trachomatis.
Genital elephantiasis or esthiomene, which is the dramatic end-result of lymphatic obstruction, which may occur because of the strictures themselves, or fistulas. This is usually seen in females, may ulcerate and often occurs 1 to 20 years after primary infection. Fistulas of, but not limited to, the penis, urethra, vagina, uterus, or rectum.
Genital elephantiasis can occur because of the blockage of the lymphatic channels due to scarring of the ulcers. There is concern that there is a linkage between donovanosis and squamous cell carcinoma .
Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. [2] [3] Usually acquired in childhood, it is a leading cause of permanent disability worldwide, impacting over a hundred million people and manifesting itself in a variety of severe clinical pathologies [6] [7] While most cases have no symptoms, some people develop a syndrome called elephantiasis, which ...
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Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized swelling caused by a compromised lymphatic system. [2] The lymphatic system functions as a critical portion of the body's immune system and returns interstitial fluid to the bloodstream.
Brugia malayi is a filarial (arthropod-borne) nematode (roundworm), one of the three causative agents of lymphatic filariasis in humans. Lymphatic filariasis, also known as elephantiasis, is a condition characterized by swelling of the lower limbs.