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The metaplastic epithelium is at the junction (center of image) and has an intensely eosinophilic (bright pink) cytoplasm. H&E stain . Metaplasia (from Greek 'change in form') is the transformation of a cell type to another cell type. [ 1 ]
Squamous metaplasia is a benign non-cancerous change of surfacing lining cells to a squamous morphology. Location Common sites for squamous ...
Metaplastic carcinoma, otherwise known as metaplastic breast cancer (MBC), is a heterogeneous group of cancers that exhibit varied patterns of metaplasia and differentiation along multiple cell lines.
Intestinal metaplasia is the transformation of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine.In the esophagus, this is called Barrett's esophagus.
A Hürthle cell is larger than a follicular cell, and polygonal with distinct cell borders. [2] Key features of these oncocytic cells include a granular cytoplasm that stains eosinophilic (pink on H&E stain ), which is commonly due to the oncocytes' high content of mitochondria , and a vesicular nucleus with a large nucleolus.
Barrett's esophagus is a condition in which there is an abnormal (metaplastic) change in the mucosal cells lining the lower portion of the esophagus, from stratified squamous epithelium to simple columnar epithelium with interspersed goblet cells that are normally present only in the small intestine and large intestine.
Recent biochemical research has shown that a deficiency in the protein tenascin-R (TNR) leads to a metaplastic increase in the threshold for LTP induction. TNR is an extracellular-matrix protein expressed by oligodendrocytes during myelination.
Autoimmune metaplastic atrophic gastritis (AMAG) is an inherited form of atrophic gastritis characterized by an immune response directed toward parietal cells and intrinsic factor. [6] Achlorhydria induces G cell (gastrin-producing) hyperplasia, which leads to hypergastrinemia.