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Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by chemotherapy, radiation therapy, migraines, or surgery. [8] It is also effective for treating gastroenteritis. [9] [10] It can be given orally (by mouth), intramuscularly (injection into a muscle), or intravenously ...
Ondansetron (Zofran) is administered in an oral tablet form, orally dissolving tablet form, orally dissolving film, sublingual, or in an IV/IM injection. Tropisetron ( Setrovel, Navoban ) can be administered in oral capsules or in injection form.
Constipation is a bowel dysfunction that makes bowel movements infrequent or hard to pass. [2] The stool is often hard and dry. [ 4 ] Other symptoms may include abdominal pain, bloating, and feeling as if one has not completely passed the bowel movement. [ 3 ]
Ondansetron is a racemate but the stereochemistry of the asymmetric carbon atom is not an important factor in the 5-HT 3 receptor interaction. Annelation of the 1,7-positions of the indole nucleus of ondansetron results in increased affinity for the receptor. [49]
Ondansetron has some utility, with a single dose being associated with less need for intravenous fluids, fewer hospitalizations, and decreased vomiting. [55] [66] [67] [68] Metoclopramide might also be helpful. [68] However, the use of ondansetron might possibly be linked to an increased rate of return to hospital in children. [69]
Constipation. Indigestion. Abdominal pain. Flu-like symptoms. Fatigue. Insomnia or trouble sleeping. Somnolescence (drowsiness) Reduced appetite. Bedroom problems like decreased libido (reduced ...
In cases of gastroenteritis, serotonin antagonists such as ondansetron were found to suppress nausea and vomiting, as well as reduce the need for IV fluid resuscitation. [22] The combination of pyridoxine and doxylamine is the first line treatment for pregnancy-related nausea and vomiting. [ 22 ]
ATC code A04 Antiemetics and antinauseants is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.