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G-quadruplex structures can be computationally predicted from DNA or RNA sequence motifs, [11] [12] but their actual structures can be quite varied within and between the motifs, which can number over 100,000 per genome. Their activities in basic genetic processes are an active area of research in telomere, gene regulation, and functional ...
The trans-form (two separate strands) of the 17E DNAzyme. Most ribonuclease DNAzymes have a similar form, consisting of a separate enzyme strand ( blue / cyan ) and substrate strand ( black ). Two arms of complementary bases flank the catalytic core ( cyan ) on the enzyme strand and the single ribonucleotide ( red ) on the substrate strand.
A final study found that female centenarians were more likely to have children in later life compared to the average, especially past the age of 40. The researchers discovered that 19.2% of female centenarians had their first child after the age of 40, compared to 5.5% of the rest of the female population. [28]
Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine , experimental gerontology , and biomedical gerontology .
This definition of immortality has been challenged in the Handbook of the Biology of Aging, [1] because the increase in rate of mortality as a function of chronological age may be negligible at extremely old ages, an idea referred to as the late-life mortality plateau. The rate of mortality may cease to increase in old age, but in most cases ...
Methylation of histones has been tied to life span regulation in many organisms, specifically H3K4me3, an activating mark, and H4K27me3, a repressing mark. In C. elegans , the loss of any of the three Trithorax proteins that catalyze the trimethylation of H3K4 such as, WDR-5 and the methyltransferases SET-2 and ASH-2, lowers the levels of ...
Free radical damage within cells has been linked to a range of disorders including cancer, arthritis, atherosclerosis, Alzheimer's disease, and diabetes. [13] There has been some evidence to suggest that free radicals and some reactive nitrogen species trigger and increase cell death mechanisms within the body such as apoptosis and in extreme ...
Some tortoises show negligible senescence. Negligible senescence is a term coined by biogerontologist Caleb Finch to denote organisms that do not exhibit evidence of biological aging (), such as measurable reductions in their reproductive capability, measurable functional decline, or rising death rates with age. [1]