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Hyperaldosteronism is a medical condition wherein too much aldosterone is produced. High aldosterone levels can lead to lowered levels of potassium in the blood ( hypokalemia ) and increased hydrogen ion excretion ( alkalosis ).
[1] [4] Some people with familial hyperaldosteronism may be treated with the steroid dexamethasone. [1] Primary aldosteronism is present in about 10% of people with high blood pressure. [1] It occurs more often in women than men. [5] Often, it begins in those between 30 and 50 years of age. [5]
The genetic conditions such as Liddle's syndrome and congenital adrenal hyperplasia present in childhood or earlier in life than the acquired causes which can present at any age. [ 1 ] [ 4 ] [ 2 ] Adult patients present with clinical history of resistant hypertension despite typical medical therapy and lifestyle changes.
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Liddle's syndrome, also called Liddle syndrome, [1] is a genetic disorder inherited in an autosomal dominant manner that is characterized by early, and frequently severe, high blood pressure associated with low plasma renin activity, metabolic alkalosis, low blood potassium, and normal to low levels of aldosterone. [1]
Familial hyperaldosteronism is a group of inherited conditions in which the adrenal glands, which are small glands located on top of each kidney, produce too much of the hormone aldosterone. [1] Excess aldosterone causes the kidneys to retain more salt than normal, which in turn increases the body's fluid levels and causes high blood pressure ...
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Renal salt wasting and high concentrations of sodium in sweat, stool, and saliva. The disorder often involves multiple organ systems and can be life threatening in the neonatal period. Patients usually present with hyponatremia, hyperkalemia, and increased plasma renin activity with high serum aldosterone concentrations.