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One example is the N-glucuronidation of an aromatic amine, 4-aminobiphenyl, by UGT1A4 or UGT1A9 from human, rat, or mouse liver. [ 2 ] The substances resulting from glucuronidation are known as glucuronides (or glucuronosides) and are typically much more water - soluble than the non-glucuronic acid-containing substances from which they were ...
The senator Robert Byrd, after winning re-election in 2000, is quoted as saying, "West Virginia has always had four friends, God Almighty, Sears Roebuck, Carter's Liver Pills and Robert C. Byrd." [6] A Carter's Little Liver Pills ad was featured in Joe Dante's 1968 collage parody film The Movie Orgy. [7]
A single slice (68 g) of beef liver exceeds the tolerable upper intake level of vitamin A (6410 μg preformed vs. UL for preformed = 3000 μg). [4] 100 g cod liver contains 5 mg of vitamin A and 100 μg of vitamin D. [5] Liver contains large amounts of vitamin B 12, and this was one of the factors that led to the discovery of the vitamin. [6]
Enterohepatic circulation of drugs. Enterohepatic circulation is the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.
Ursodeoxycholic acid (UDCA), also known as ursodiol, is a secondary bile acid, produced in humans and most other species from metabolism by intestinal bacteria.It is synthesized in the liver in some species, and was first identified in bile of bears of genus Ursus, from which its name derived. [8]
Liver regeneration is the process by which the liver is able to replace damaged or lost liver tissue. The liver is the only visceral organ with the capacity to regenerate. [ 1 ] [ 2 ] The liver can regenerate after partial hepatectomy or injury due to hepatotoxic agents such as certain medications, toxins, or chemicals. [ 3 ]
Macrolides exhibit enterohepatic recycling; that is, the drug is absorbed in the gut and sent to the liver, only to be excreted into the duodenum in bile from the liver. This can lead to a buildup of the product in the system, thereby causing nausea. In infants the use of erythromycin has been associated with pyloric stenosis.
Andrews Liver Salts was a laxative and antacid for mild stomach complaints. It was sold as a powder which is added to water and mixed, creating effervescence , before being swallowed. The powder contains sugar; an antacid, sodium bicarbonate (22.6% w/w); citric acid (to provide effervescence) (19.5% w/w); and a laxative, magnesium sulphate (17. ...