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Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]
Blocking or disrupting blood flow to the heart is what causes a heart attack, while blocked or disrupted blood flow to the head causes a stroke. ... in the deep veins of the legs," Blaha says. "In ...
The illustration shows how PAD can affect the legs' arteries. Figure A shows a normal artery with normal blood flow. The inset image shows a cross-section of the normal artery. Figure B shows an artery with plaque buildup partially blocking blood flow. The inset image shows a cross-section of the narrowed artery.
Often expressed in cm/s. This value is inversely related to the total cross-sectional area of the blood vessel and also differs per cross-section, because in normal condition the blood flow has laminar characteristics. For this reason, the blood flow velocity is the fastest in the middle of the vessel and slowest at the vessel wall.
Angiography is also commonly performed to identify vessels narrowing in patients with leg claudication or cramps, caused by reduced blood flow down the legs and to the feet; in patients with renal stenosis (which commonly causes high blood pressure) and can be used in the head to find and repair stroke. These are all done routinely through the ...
Nearly half of U.S. adults still believe that the benefits of taking low-dose aspirin daily outweighs the risks — despite new guidance that suggests otherwise, according to a new survey. The ...
Compression stockings are elastic compression garments worn around the leg, compressing the limb. This reduces the diameter of distended veins and increases venous blood flow velocity and valve effectiveness. Compression therapy helps decrease venous pressure, prevents venous stasis and impairments of venous walls, and relieves heavy and aching ...
Peripheral artery disease – occurs when atheromatous plaques build up in the arteries that supply blood to the arms and legs, causing the arteries to narrow or become blocked. [ 1 ] Erythromelalgia - a rare peripheral vascular disease with symptoms that include burning pain, increased temperature, erythema and swelling that generally affect ...