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n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a Wikidata View/Edit Human Immunoglobulin heavy locus, also known as IGH, is a region on human chromosome 14 that contains a gene for the heavy chains of human antibodies (or immunoglobulins). Immunoglobulins recognize foreign antigens and initiate immune responses such as ...
Despite the high sequence similarity (90% identical on the amino acid level), each subclass has a different half-life, a unique profile of antigen binding and distinct capacity for complement activation. IgG1 antibodies are the most abundant IgG class and dominate the responses to protein antigens.
Heavy chains μ and ε have a constant region composed of four domains. [4] a variable region that differs between different B cells, but is the same for all immunoglobulins produced by the same B cell or B cell clone. The variable domain of any heavy chain is composed of a single immunoglobulin domain. These domains are about 110 amino acids ...
The water-accessible surface area of an IgG antibody. Immunoglobulin G (IgG) is a type of antibody.Representing approximately 75% of serum antibodies in humans, IgG is the most common type of antibody found in blood circulation. [1]
This region allows antibodies to activate the immune system, for example, through binding to Fc receptors. In IgG , IgA and IgD antibody isotypes , the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody's two heavy chains ; IgM and IgE Fc regions contain three heavy chain ...
This is a recombinant monoclonal antibody to rhesus IgG1. It specifically reacts with rhesus IgG1 via ELISA. Specificity of anti-rhesus IgG1 to rhesus IgG1 was confirmed through antibody responses to HIV-1 vaccine in rhesus macaques. [29] Anti-Rhesus IgG4 [2C6] This is a recombinant monoclonal antibody to rhesus IgG4.
Each antibody binds to a specific antigen in a highly specific interaction analogous to a lock and key.. An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that cause disease.
3500 n/a Ensembl ENSG00000211896 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 14: 105.74 – 105.74 Mb n/a PubMed search n/a Wikidata View/Edit Human Ig gamma-1 chain C region is a protein that in humans is encoded by the IGHG1 gene. References ^ a b c GRCh38: Ensembl release 89: ENSG00000211896 – Ensembl, May 2017 ^ "Human PubMed Reference ...