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Lorcaserin, marketed under the brand name Belviq, [4] [5] was a weight-loss drug developed by Arena Pharmaceuticals.It reduces appetite by activating serotonin receptor the 5-HT 2C receptor in the hypothalamus, a region of the brain which is known to control appetite. [6]
Lorcaserin (Belviq) was FDA approved for weight loss but was withdrawn from the market because a safety clinical trial shows an increased occurrence of cancer. [ 11 ] Cannabinoid receptor antagonists were developed to treat obesity because researchers noticed that cannabinoid agonists (such as THC , the main pharmacologically active component ...
Bust out the milkshakes: Arena Pharmaceuticals' (NAS: ARNA) obesity drug lorcaserin, now called Belviq, won the approval of the Food and Drug Administration today. My theory that the drug would ...
Lorcaserin is approved for use in adults with a body mass index (BMI) of 30 or greater, which is considered obese, or adults with a BMI of 27 or greater and who have at least one weight-related health condition, such as high blood pressure, type 2 diabetes, or high cholesterol. However, sales of Belviq were disappointing.
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Lorcaserin is a very potent agonist, but the potency is dependent on the presence of a chloro substituent in position 8. [ 7 ] [ 33 ] [ 34 ] Arylpiperazine-containing compounds such as mCPP (Figure 7), show good potency toward the 5-HT 2C receptors, but do not have sufficient selectivity for the 5-HT 2C receptors over the other two receptor ...
Lorcaserin (Belviq) 2020 US Increased risk of cancer. [32] Lumiracoxib (Prexige) 2007–2008 Worldwide Liver damage Lysergic acid diethylamide (LSD) 1950s–1960s Marketed as a psychiatric drug; withdrawn after it became widely used recreationally. Now illegal in most of the world. Mebanazine: 1975 UK Hepatotoxicity, drug intereaction. [3 ...
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