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Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [ 6 ] [ 8 ] It is a nicotinic acetylcholine receptor partial agonist .
The diocese had its roots in the East Saxon kingdom, and was probably originally larger than shown here. The modern English county of Essex maintains the historic northern and the southern borders, but only covers the territory east of the River Lea , the other parts being lost to neighbouring Mercia during the 8th century.
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The Heptarchy is the name for the division of Anglo-Saxon England between the sixth and eighth centuries into petty kingdoms, conventionally the seven kingdoms of East Anglia, Essex, Kent, Mercia, Northumbria, Sussex, and Wessex.
Schwyzer states that Raphael Holinshed's 1577 Chronicles of England, Scotland, and Ireland is the first work of historiography to deal with the British Isles in particular; "To the best of my knowledge, no book published in England before 1577 specified in its title a scope at once inclusive of and restricted to England, Scotland, and Ireland".
Britain in Bloom divides England into 12 regions, bearing a mixture of government regions with some altered names. It also includes Cumbria , Thames-and-Chilterns ( Berkshire , Buckinghamshire and Oxfordshire ) and part of south east and south west as South-and-South-West.
England, as part of the UK, joined the European Economic Community in 1973, which became the European Union in 1993. The UK left the EU in 2020. There is a movement in England to create a devolved English Parliament. This would give England a local Parliament like those already functioning for Scotland, Northern Ireland and Wales.
For much of the Middle Ages, England's climate differed from that in the twenty-first century. Between the ninth and thirteenth centuries England went through the Medieval Warm Period , a prolonged period of warmer temperatures; in the early thirteenth century, for example, summers were around 1 °C warmer than today and the climate was ...