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Ambroxol is a drug that breaks up phlegm, used in the treatment of respiratory diseases associated with viscid or excessive mucus. Ambroxol is often administered as an active ingredient in cough syrup. It was patented in 1966 and came into medical use in 1979. [1]
Moulded on the sides of this 5-inch tall glass bottle are the inscriptions MRS. WINSLOWS / SOOTHING SYRUP / CURTIS & PERKINS / PROPRIETORS. Mrs. Winslow's Soothing Syrup was a patent medicine supposedly compounded by Mrs. Charlotte N. Winslow, and first marketed by her son-in-law Jeremiah Curtis [1] and Benjamin A. Perkins of Bangor, Maine, United States [2] in 1845. [3]
The number of pet dogs jumped as much as 16% between 2016 and 2020, while pet cats climbed as much as 6%, according to the American Veterinary Medical Association.
A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity. [3]As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class.
In 1944, two clinicians who evaluated the expectorant action of paregoric, concluded: The survival of paregoric through the centuries, and particularly through recent critical decades, is probably due to keen clinical observation and stubborn adherence to the clinical deduction that paregoric is useful in certain types of cough.
Erdosteine is a molecule with mucolytic activity. Structurally it is a thioether derivative with two thioether groups. [1] These two functional organosulfur groups contained in the molecule are released following first-pass metabolism with the conversion of erdosteine into its pharmacologically active metabolite Met-I.
Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). [3] Like other NSAIDs, its effects are caused by inhibition of cyclooxygenase (COX) enzymes. [7] At the doses used to treat dogs, deracoxib causes greater inhibition of COX-2 than of COX-1, [3] but at doses twice those recommended for use in dogs, deracoxib significantly inhibits COX-1 as well.
Phenobarbital is one of the first-line drugs of choice to treat epilepsy in dogs, as well as cats. [11] It is also used to treat feline hyperesthesia syndrome in cats when anti-obsessional therapies prove ineffective. [72] It may also be used to treat seizures in horses when benzodiazepine treatment has failed or is contraindicated. [73]