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The Battle of Antietam (/ æ n ˈ t iː t əm / an-TEE-təm), also called the Battle of Sharpsburg, particularly in the Southern United States, took place during the American Civil War on September 17, 1862, between Confederate General Robert E. Lee's Army of Northern Virginia and Union Major General George B. McClellan's Army of the Potomac near Sharpsburg, Maryland, and Antietam Creek.