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A549 has also been employed in viral research and associated protein expression changes as a consequence of viral infection. [10] Although A549 is a cancer cell line, it has also been studied for its response to tuberculosis, specifically the production of chemokines as it is induced by the invading bacteria. [11]
The Atlas is part of the genome project and participates in research on cancer epidemiology. The Atlas is accessed by: 1- researchers in cytogenetics, molecular biology, cell biology; 2- clinicians, haematologists, cytogeneticists, pathologists, from the university hospitals, indeed, but also from general hospitals where the Atlas is one of the ...
The panel holds cell lines representing leukemia, melanoma, non-small-cell lung carcinoma, and cancers of the brain, ovary, breast, colon, kidney, and prostate. [1] [2]13 additional cell lines are evaluated for use in the screening program, among them two lines deriving from so far not represented small-cell lung carcinoma.
Among the products of the program is the Azimuth reference datasets for single-cell RNA seq data [2] [3] and the ASCT+B Reporter, a visualization tool for anatomical structures, cell types and biomarkers. [4] [5] Millitomes are used to create uniformly sized tissue blocks that match the shape and size of organs from HuBMAP's 3D Reference Object ...
Lewis lung carcinoma is a hypermutated Kras/Nras–mutant cancer with extensive regional mutation clusters in its genome. A tumor that spontaneously developed as an epidermoid carcinoma in the lung of a C57BL mouse. It was discovered in 1951 by Dr. Margaret Lewis of the Wistar Institute and became one of the first transplantable tumors. [1]
The Cancer Genome Atlas (TCGA) is a project to catalogue the genomic alterations responsible for cancer using genome sequencing and bioinformatics. [1] [2] The overarching goal was to apply high-throughput genome analysis techniques to improve the ability to diagnose, treat, and prevent cancer through a better understanding of the genetic basis of the disease.
An initial release of the first atlas, the mouse brain atlas, occurred in December 2004. Subsequently, more data for this atlas was released in stages. The final genome-wide data set was released in September 2006. However, the final release of the atlas was not the end of the project; the Atlas is still being improved upon.
Pie chart showing incidence of large-cell lung cancer (shown in green at upper left) as compared to other lung cancer types, with fractions of smokers versus non-smokers shown for each type. [ 7 ] In most series, LCLC's comprise between 3%-9% of all primary lung cancers .
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