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The first recorded knockout mouse was created by Mario R. Capecchi, Martin Evans, and Oliver Smithies in 1989, for which they were awarded the 2007 Nobel Prize in Physiology or Medicine. Aspects of the technology for generating knockout mice, and the mice themselves have been patented in many countries by private companies.
The International Knockout Mouse Consortium (IKMC) is a scientific endeavour to produce a collection of mouse embryonic stem cell lines that together lack every gene in the genome, and then to distribute the cells to scientific researchers to create knockout mice to study.
The International Mouse Phenotyping Consortium (IMPC) is an international scientific endeavour to create and characterize the phenotype of 20,000 knockout mouse strains. [1] [2] [3] Launched in September 2011, [1] the consortium consists of over 15 research institutes across four continents with funding provided by the NIH, European national governments and the partner institutions.
The Mouse Genetics Project (MGP) is a large-scale mutant mouse production and phenotyping programme aimed at identifying new model organisms of disease. [1] [2] [3] [4]Based at the Wellcome Trust Sanger Institute, the project uses knockout mice most of which were generated by the International Knockout Mouse Consortium.
Today the Biohub is launching Tabula Muris, an open-source database that details the biology of the average healthy mouse cell-by-cell, providing a potential gold mine for medical researchers.
The Mouse Phenome Database (MPD) is a web-accessible database of strain characterization data for the laboratory mouse, to facilitate translational research for human health and disease. MPD characterizes phenotype as well as genotype , and provides tools for online analysis.
Europhenome [1] [2] is a resource for presenting, searching and analysing mouse phenotypes that were revealed by high throughput mouse phenotyping [3] programmes such as EUMODIC. The EuroPhenome project provides access to raw and annotated mouse phenotyping data generated from primary pipelines such as EMPReSSlim and secondary procedures from ...
The genetically modified mouse in which a gene affecting hair growth has been knocked out (left) shown next to a normal lab mouse. A genetically modified mouse, genetically engineered mouse model (GEMM) [1] or transgenic mouse is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques.