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  2. Fatal insomnia - Wikipedia

    en.wikipedia.org/wiki/Fatal_insomnia

    Fatal insomnia is an extremely rare neurodegenerative prion disease that results in trouble sleeping as its hallmark symptom. [2] The majority of cases are familial (fatal familial insomnia [FFI]), stemming from a mutation in the PRNP gene, with the remainder of cases occurring sporadically (sporadic fatal insomnia [sFI]).

  3. Familial sleep traits - Wikipedia

    en.wikipedia.org/wiki/Familial_sleep_traits

    Fatal Familial Insomnia (FFI) is a disorder that results in trouble sleeping, speech and coordination problems, and eventually dementia. Most of those affected die within a few years, and the disorder has no cure. The disorder can manifest any time from age 18 to 60, but the average age of affected individuals is 50 years old. [19]

  4. Transmissible spongiform encephalopathy - Wikipedia

    en.wikipedia.org/wiki/Transmissible_spongiform...

    TSEs of humans include Creutzfeldt–Jakob disease, Gerstmann–Sträussler–Scheinker syndrome, fatal familial insomnia, and kuru, as well as the recently discovered variably protease-sensitive prionopathy and familial spongiform encephalopathy. Creutzfeldt-Jakob disease itself has four main forms, the sporadic (sCJD), the hereditary/familial ...

  5. Insomnia - Wikipedia

    en.wikipedia.org/wiki/Insomnia

    A rare genetic condition can cause a prion-based, permanent and eventually fatal form of insomnia called fatal familial insomnia [66] Physical exercise: exercise-induced insomnia is common in athletes in the form of prolonged sleep onset latency [67] Increased exposure to the blue light from artificial sources, such as phones or computers [68]

  6. Major prion protein - Wikipedia

    en.wikipedia.org/wiki/Major_prion_protein

    fatal familial insomnia – aspartic acid-178 is replaced by asparagine while methionine is present at amino acid 129 [53] The conversion of PrP C to PrP Sc conformation is the mechanism of transmission of fatal, neurodegenerative transmissible spongiform encephalopathies (TSE). This can arise from genetic factors, infection from external ...

  7. Sleep disorder - Wikipedia

    en.wikipedia.org/wiki/Sleep_disorder

    Fatal familial insomnia, an extremely rare and universally-fatal prion disease that causes a complete cessation of sleep. Hypopnea syndrome , abnormally shallow breathing or slow respiratory rate while sleeping.

  8. Sleep state misperception - Wikipedia

    en.wikipedia.org/wiki/Sleep_state_misperception

    Cases of objective total insomnia are extremely rare. The few that have been recorded have predominantly been ascribed to a rare incurable genetic disorder called fatal familial insomnia, which patients rarely survive for more than 26 months after the onset of illness—often much less. [19]

  9. Familial fatal insomnia - Wikipedia

    en.wikipedia.org/?title=Familial_fatal_insomnia&...

    Pages for logged out editors learn more. Contributions; Talk; Familial fatal insomnia