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Semen extender is a liquid diluent which is added to semen to preserve its fertilizing ability. It acts as a buffer to protect sperm cells from their own toxic byproducts, as well as protecting the sperm from cold shock and osmotic shock during the chilling and shipping process (the semen is chilled to reduce metabolism).
The most common cryoprotectant used for semen is glycerol (10% in culture medium). Often sucrose or other di-, trisaccharides are added to glycerol solution. Cryoprotectant media may be supplemented with either egg yolk or soy lecithin, with the two having no statistically significant differences compared to each other regarding motility, morphology, ability to bind to hyaluronate in vitro, or ...
When performing cryopreservation of semen, it is the sperm quality after reviving the sample that is of importance, because many sperm cells die in the process. To be of use in assisted reproductive technology , the sample should after thawing have more than 5 million motile sperm cells per ml with a good grade of mobility.
Lecithin contains dietary precursors to choline, an essential nutrient, which was formerly classified as a B vitamin (vitamin B 4). [17] [18] Lecithin is a mixture of fats that contains phospholipids, including phosphatidylcholine, and the human body can convert phosphatidylcholine into choline.
Common inherited variants in genes that encode enzymes employed in DNA mismatch repair are associated with increased risk of sperm DNA damage and male infertility. [39] As men age there is a consistent decline in semen quality, and this decline appears to be due to DNA damage. [40]
Sperm motility is dependent on several metabolic pathways and regulatory mechanisms. The axonemal bend movement is based on the active sliding of axonemal doublet microtubules by the molecular motor dynein, which is divided into an outer and an inner arm. Outer and inner arm plays different roles in the production and regulation of flagellar motility: the outer arm increase the bea
Phosphatidylcholine is the major component of lecithin. It is also a source for choline in the synthesis of acetylcholine in cholinergic neurons. Phospholipids [ 1 ] are a class of lipids whose molecule has a hydrophilic "head" containing a phosphate group and two hydrophobic "tails" derived from fatty acids , joined by an alcohol residue ...
Researchers have also shown that despite a good prognosis and having the finances available to pay for treatment, discontinuation is most often due to psychological reasons. [18] Fertility does not seem to increase when the women takes antioxidants to reduce the oxidative stress brought by the situation. [19] Infertility may have psychological ...
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