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  2. Clark's rule - Wikipedia

    en.wikipedia.org/wiki/Clark's_rule

    Clark's rule is a medical term referring to a mathematical formula used to calculate the proper dosage of medicine for children aged 2–17 based on the weight of the patient and the appropriate adult dose. [1] The formula was named after Cecil Belfield Clarke (1894–1970), a Barbadian physician who practiced throughout the UK, the West Indies ...

  3. Vancomycin - Wikipedia

    en.wikipedia.org/wiki/Vancomycin

    The recommended oral dosage in the treatment of antibiotic-induced pseudomembranous enterocolitis is 125 to 500 mg every 6 hours for 7 to 10 days. [53] Dose optimization and target attainment of vancomycin in children involves adjusting the dosage to maximize effectiveness while minimizing the risk of adverse effects, specifically acute kidney ...

  4. Congenital chloride diarrhea - Wikipedia

    en.wikipedia.org/wiki/Congenital_chloride_diarrhea

    CCD may be detectable on prenatal ultrasound. [4] [5] After birth, signs in affected babies typically are abdominal distension, visible peristalsis, and watery stools persistent from birth that show chloride loss of more than 90 mmol/L. [5] An important feature in this diarrhea that helps in the diagnosis, is that it is the only type of diarrhea that causes metabolic alkalosis rather than ...

  5. Chronic diarrhea of infancy - Wikipedia

    en.wikipedia.org/wiki/Chronic_diarrhea_of_infancy

    Chronic diarrhea (alternate spelling: diarrhoea) of infancy, also called toddler's diarrhea, is a common condition typically affecting up to 1.7 billion children between ages 6–30 months worldwide every year, usually resolving by age 4.

  6. Glycopeptide antibiotic - Wikipedia

    en.wikipedia.org/wiki/Glycopeptide_antibiotic

    Glycopeptide antibiotics are a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic nonribosomal peptides.Significant glycopeptide antibiotics include the anti-infective antibiotics vancomycin, teicoplanin, telavancin, ramoplanin, avoparcin and decaplanin, corbomycin, complestatin and the antitumor antibiotic bleomycin.

  7. Area under the curve (pharmacokinetics) - Wikipedia

    en.wikipedia.org/wiki/Area_under_the_curve...

    Absolute bioavailability refers to the bioavailability of a drug when administered via an extravascular dosage form (i.e. oral tablet, suppository, subcutaneous, etc.) compared with the bioavailability of the same drug administered intravenously (IV). This is done by comparing the AUC of the non-intravenous dosage form with the AUC for the drug ...

  8. Small intestinal bacterial overgrowth - Wikipedia

    en.wikipedia.org/wiki/Small_intestinal_bacterial...

    First, the excessive bacterial concentrations can cause direct inflammation of the small bowel cells, leading to an inflammatory diarrhea. The malabsorption of lipids, proteins and carbohydrates may cause poorly digestible products to enter into the colon. This can cause an osmotic diarrhea or stimulate the colonic cells to cause a secretory ...

  9. Dose (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Dose_(biochemistry)

    In single-dose scenarios, the patient's body weight and the drug's recommended dose per kilogram are used to determine a safe one-time dose. If multiple doses of treatment are needed in a day, the physician must take into account information regarding the total amount of the drug which is safe to use in one day, and how that should be broken up ...