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  2. Adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_receptor

    Epinephrine (adrenaline) reacts with both α- and β-adrenoreceptors, causing vasoconstriction and vasodilation, respectively. Although α receptors are less sensitive to epinephrine, when activated at pharmacologic doses, they override the vasodilation mediated by β-adrenoreceptors because there are more peripheral α 1 receptors than β ...

  3. Alpha-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Alpha-1_adrenergic_receptor

    In contrast to α 2-adrenergic receptors, α 1-adrenergic-receptors in the arterial vasculature of skeletal muscle are more resistant to inhibition, and attenuation of α1-adrenergic-receptor-mediated vasoconstriction only occurs during heavy exercise. [18] Note that only active muscle α 1-adrenergic receptors will

  4. Beta-1 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-1_adrenergic_receptor

    The beta-1 adrenergic receptor (β 1 adrenoceptor), also known as ADRB1, can refer to either the protein-encoding gene (gene ADRB1) or one of the four adrenergic receptors. [5] It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein that is expressed predominantly in cardiac tissue. In addition to cardiac tissue, beta ...

  5. Vascular smooth muscle - Wikipedia

    en.wikipedia.org/wiki/Vascular_smooth_muscle

    alpha-1 receptors. Under NE binding alpha-1 receptors cause vasoconstriction (contraction of the vascular smooth muscle cells decreasing the diameter of the vessels). These receptors are activated in response to shock or low blood pressure as a defensive reaction trying to restore the normal blood pressure.

  6. Adrenergic antagonist - Wikipedia

    en.wikipedia.org/wiki/Adrenergic_antagonist

    Adrenergic antagonists reverse the natural cardiovascular effect, based on the type of adrenoreceptor being blocked. For example, if the natural activation of the α 1-adrenergic receptor leads to vasoconstriction, an α 1-adrenergic antagonist will result in vasodilation. [3]

  7. Sympathetic nervous system - Wikipedia

    en.wikipedia.org/wiki/Sympathetic_nervous_system

    This secondary vasodilation caused by the primary vasoconstriction is termed functional sympatholysis, the overall effect of which on coronary arteries is dilation. [12] The target synapse of the postganglionic neuron is mediated by adrenergic receptors and is activated by either norepinephrine (noradrenaline) or epinephrine (adrenaline).

  8. Beta-2 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Beta-2_adrenergic_receptor

    The beta-2 adrenergic receptor (β 2 adrenoreceptor), also known as ADRB2, is a cell membrane-spanning beta-adrenergic receptor that binds epinephrine (adrenaline), a hormone and neurotransmitter whose signaling, via adenylate cyclase stimulation through trimeric G s proteins, increases cAMP, and, via downstream L-type calcium channel interaction, mediates physiologic responses such as smooth ...

  9. Sympathoadrenal system - Wikipedia

    en.wikipedia.org/wiki/Sympathoadrenal_system

    The mechanism lies in epinephrine being secreted by the adrenal medulla and activating glycogenolysis (the breakdown of glycogen into glucose, or promoting gluconeogenesis (glucose formation). While epinephrine has a greater effect in glucose production, norepinephrine can also increase glucose levels but at high concentrations.

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