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In dermatopathology, the Tzanck test, also Tzanck smear, is scraping of an ulcer base to look for Tzanck cells. It is sometimes also called the chickenpox skin test and the herpes skin test. It is a simple, low-cost, and rapid office based test. [1] Tzanck cells (acantholytic cells) are found in: Herpes simplex [2] Varicella and herpes zoster
Many skin conditions require a skin biopsy for confirmation of the diagnosis. With several of these conditions there are features within the cells contained in the skin biopsy specimen that have elements in their cytoplasm or nucleus that have a characteristic appearance unique to the condition. These elements are termed inclusion bodies.
Acantholysis is the loss of intercellular connections, such as desmosomes, resulting in loss of cohesion between keratinocytes, [1] seen in diseases such as pemphigus vulgaris. [2]
Dermatology Grover's disease ( GD ) is a polymorphic, pruritic , papulovesicular dermatosis characterized histologically by acantholysis [ 2 ] : 529 with or without dyskeratosis. [ 3 ] Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient".
Often numerous plasma cells in about 1/3 of cases; Often endothelial swelling. Erythema migrans Typically a superficial and deep perivascular lymphocytic infiltrate. [22] Plasma cells are typically located at the periphery of the lesion, whereas eosinophils are in the center. [22] Kaposi’s sarcoma in patch stage
Acantholytic dyskeratotic epidermal nevus is a cutaneous condition identical to the generalized form of Darier's disease. [ 1 ] : 849 "Acantholytic dyskeratotic epidermal nevus" is probably the same disorder.
Epidermolytic acanthoma manifests clinically as tiny, fleshy or white papules that range in size from 1 to 2 mm. They may exist alone or in groups. [2] [3] They often affect the trunk, extremities, or scrotum and vulva. [4]
Robinson then took on administrative positions and became Director of the Division of Dermatology at Loyola University in Chicago from 1998 till 2004. In the following year, she served as Section Chief of Dermatology at Dartmouth- Hitchcock Medical Center before rejoining Northwestern University in 2005, as a Research Professor of Dermatology ...
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