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Cerebral edema is a potentially life-threatening complication of severely decreased sodium ion concentration in the blood (hyponatremia). [17] Ionic brain edema can also occur around the sites of brain hemorrhages, infarcts, or contusions due to a local plasma osmolality pressure gradient when compared to the high osmolality in the affected tissue.
Neonatal encephalopathy (NE), previously known as neonatal hypoxic-ischemic encephalopathy (neonatal HIE or NHIE), is defined as a encephalopathy syndrome with signs and symptoms of abnormal neurological function, in the first few days of life in an infant born after 35 weeks of gestation.
Clinical signs of cerebral edema, such as focal neurological deficits, papilledema [5] and decreased level of consciousness, if temporally associated with recent hemodialysis, suggest the diagnosis. A computed tomography of the head is typically done to rule-out other intracranial causes.
Of those who have residual symptoms after PRES, this is attributable largely to hemorrhage. [1] [4] Non-resolution of MRI abnormalities has been linked with poorer outcomes. [4] The presence of brain hemorrhage and cytotoxic edema (brain edema with concomittant brain tissue damage) is also associated with a poor prognosis. [2]
The sudden collapse seen in patients may be due to a type of cerebral edema that can follow an initial impact in children and teenagers, rather than to SIS. [45] This type of edema, referred to as diffuse cerebral swelling , may be the real reason for the collapse which young people sometimes experience and which is commonly thought to be due ...
Lee's death was officially ruled the result of cerebral edema — swelling of the brain. While a normal human brain is about 3 pounds, Lee's was reportedly closer to 3½ pounds.
ARIA-E refers to cerebral edema, involving the breakdown of the tight endothelial junctions of the blood-brain barrier and subsequent accumulation of fluid. [3] In a double-blind trial of the humanised monoclonal antibody solanezumab (n = 2042), sixteen patients (11 taking the drug, 5 taking a placebo), or 0.78% developed ARIA-E.
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