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Pantoprazole, sold under the brand name Protonix, among others, is a medication used for the treatment of stomach ulcers, short-term treatment of erosive esophagitis due to gastroesophageal reflux disease (GERD), maintenance of healing of erosive esophagitis, and pathological hypersecretory conditions including Zollinger–Ellison syndrome.
Pantoprazole was first prepared in April 1985 by a small group of scale-up chemists. It is a dimethoxy-substituted pyridine bound to a fluoroalkoxy substituted benzimidazole. [5] Pantoprazole sodium is available as gastroresistant or delayed release tablets and as lyophilized powder for intravenous use.
[19] [20] [21] In the United States, the Food and Drug Administration (FDA) has advised that over-the-counter PPIs, such as Prilosec OTC, should be used no more than three 14-day treatment courses over one year. [22] [23] Despite their extensive use, the quality of the evidence supporting their use in some of these conditions is variable.
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A fluid ounce (abbreviated fl oz, fl. oz. or oz. fl., old forms ℥, fl ℥, f℥, ƒ ℥) is a unit of volume (also called capacity) typically used for measuring liquids. The British Imperial , the United States customary , and the United States food labeling fluid ounce are the three that are still in common use, although various definitions ...
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The University of Oxford team reported: “For women with PCOS, our systematic review suggests weight loss interventions led to improvements in some important clinical features of PCOS.”
Single 20 to 40 mg oral doses generally give rise to peak plasma esomeprazole concentrations of 0.5-1.0 mg/L within 1–4 hours, but after several days of once-daily administration, these levels may increase by about 50%. A 30-minute intravenous infusion of a similar dose usually produces peak plasma levels on the order of 1–3 mg/L. The drug ...