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Heat stress can result in heat-related illnesses, such as heat stroke, hyperthermia, heat exhaustion, heat cramps, heat rashes, and chronic kidney disease (CKD). [2] [3] Although heat exhaustion is less severe, heat stroke is a medical emergency and requires emergency treatment, which if not provided, can lead to death. [4]
Heat illness is a spectrum of disorders due to increased body temperature. It can be caused by either environmental conditions or by exertion. It includes minor conditions such as heat cramps, heat syncope, and heat exhaustion as well as the more severe condition known as heat stroke. [1] It can affect any or all anatomical systems. [2]
An early stage of hyperthermia can be "heat exhaustion" (or "heat prostration" or "heat stress"), whose symptoms can include heavy sweating, rapid breathing and a fast, weak pulse. If the condition progresses to heat stroke, then hot, dry skin is typical [ 2 ] as blood vessels dilate in an attempt to increase heat loss.
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
Children (under the age of 18 years old) have a lower heat tolerance compared to adults due to decreased homeostatic regulatory systems, increased metabolic rates, and decreased cardiac output. [22] Strenuous exercise in high-temperature conditions is the leading cause of heat-related illness in children.
During the heat up the surface is relatively hotter and will expand more than the center. An example of this is dental fillings can cause thermal stress in a person's mouth. Sometimes dentists use dental fillings with different thermal expansion coefficients than tooth enamel, the fillings will expand faster than the enamel and cause pain in a ...
Heat stroke results in more than 600 deaths a year in the United States. [4] Rates increased between 1995 and 2015. [3] Purely exercise-induced heat stroke, though a medical emergency, tends to be self-limiting (the patient stops exercising from cramp or exhaustion) and fewer than 5% of cases are fatal.
Heat-shock proteins can be secreted from immune cells or tumour cells by non-canonical secretion pathway, or leaderless pathway, because they do not have the leader peptide, which navigate proteins into endoplasmic reticulum. The non-canonical secretion can be similar to the one, which occurs for IL1 b, and it is induced by stress conditions. [30]