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Some lesser known uses are as a means of high-dose estrogen therapy in the treatment of breast cancer in both women and men and in the treatment of prostate cancer in men. [ 22 ] [ 23 ] It has been used at a dosage of 2.5 mg three times per day (7.5 mg/day total) for prostate cancer.
The application of utilizing eFSH to increase the efficiency of equine embryo transfer was tested at the University of Saskatchewan.Embryos from 12 donor mares at 8 days of ovulation were recovered, scored, then transferred to 37 recipients mares who were tested for pregnancy after 7-10 days. 5 pregnancies resulted from the 15 embryos were recovered from the eFSA treatment group and 4 ...
Estradiol has been used at high doses to suppress sex drive in men with sexual deviance such as paraphilias and in sex offenders. [84] [85] [86] It has specifically been used for this indication in the forms of intramuscular injections of estradiol valerate and estradiol undecylate and of subcutaneous pellet implants of estradiol. [84] [85] [86]
Estrone is an estrogen, specifically an agonist of the estrogen receptors (ERs) ERα and ERβ. [5] [44] It is a far less potent estrogen than is estradiol, and as such is a relatively weak estrogen. [5] [44] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol. [45]
Esterified estrogens (EEs), sold under the brand names Estratab and Menest among others, is an estrogen medication which is used hormone therapy for menopausal symptoms and low sex hormone levels in women, to treat breast cancer in both women and men, and to treat prostate cancer in men.
Tritiated estradiol radioactivity in blood with a single intramuscular injection of 1.5 to 2.8 μg tritiated estradiol in aqueous solution in four women. [1] Peak blood radioactivity occurred within 15 minutes in three of the women and in the remaining woman after 2 hours. [1] Source: Davis et al. (1963). [1]
In another study, a dosage of 1 mg/day oral micronized estradiol in healthy older men, which increased circulating estradiol levels by a relatively high amount of 6-fold (to 159 pg/mL), estrone levels by 15-fold (to 386 pg/mL), and SHBG levels by 17%, was found to suppress total testosterone levels by 27% (to 436 ng/dL) and free testosterone ...