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Cannabis use disorder (CUD), also known as cannabis addiction or marijuana addiction, is a psychiatric disorder defined in the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders and ICD-10 as the continued use of cannabis despite clinically significant impairment. [2] [3]
As of 2022, no disease-modifying drugs (drugs that target the causes or damage) are approved for Parkinson's, so this is a major focus of Parkinson's research. [ 262 ] [ 263 ] Active research directions include the search for new animal models of the disease and studies of the potential usefulness of gene therapy , stem cell transplants, and ...
Parkinsonism is a clinical syndrome characterized by the four motor symptoms found in Parkinson's disease: tremor, bradykinesia (slowed movements), rigidity, and postural instability. [ 1 ] [ 2 ] Parkinsonism gait problems can lead to falls and serious physical injuries.
Pick's disease with Pick bodies; Lewy body dementias; Neurofilament inclusion body disease; Creutzfeldt–Jakob disease; Frontotemporal degeneration due to progranulin gene mutation; Motor neuron diseaseâinclusion dementia. [9] The symptoms of classic CBS differ from CBD in that CBD also includes cognitive deficits in the executive functions ...
Parkinson's disease (PD), the second most common neurodegenerative disease after Alzheimer's disease, affects 1% of people over 60 years of age. [1] [2] [3] In the past three decades, the number of PD cases has doubled globally from 2.5 million in 1990 to 6.1 million in 2016. [4] [5] As of 2022, there are ~10 million PD cases globally. [6]
Number with a drug use disorders by substance, OWID. Substance-related disorders, also known as substance use disorders, can lead to large societal problems.It is found to be greatest in individuals ages 18–25, with a higher likelihood occurring in men compared to women, and urban residents compared to rural residents.
Parkinson-plus syndromes are usually more rapidly progressive and less likely to respond to antiparkinsonian medication than PD. [10] [11] However, the additional features of the diseases may respond to medications not used in PD. [citation needed] Current therapy for Parkinson-plus syndromes is centered around a multidisciplinary treatment of ...
Cotinine is an alkaloid found in tobacco [1] and is also the predominant metabolite of nicotine, [2] [3] typically used as a biomarker for exposure to tobacco smoke. Cotinine is currently being studied as a treatment for depression, post-traumatic stress disorder (PTSD), schizophrenia, Alzheimer's disease and Parkinson's disease.