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Persistently high LH levels are indicative of situations where the normal restricting feedback from the gonad is absent, leading to a pituitary production of both LH and FSH. While this is typical in menopause, it is abnormal in the reproductive years. There it may be a sign of: Premature menopause
Eventually, the FSH level becomes so high that downregulation of FSH receptors occurs and by postmenopause any remaining small secondary follicles no longer have FSH nor LH receptors. [14] When the follicle matures and reaches 8–10 mm in diameter it starts to secrete significant amounts of estradiol.
Urine of postmenopausal women reflects the hypergonadotropic state of menopause-levels of follicle stimulating hormone (FSH) and luteinizing hormone (LH) are high - and contain a mixture of these gonadotropins. [2] [3] [4] Other protein substances may be present, including small amounts of human chorionic gonadotropin (hCG). [1]
Hot flashes, or flushes, are commonly associated with menopause in women. ... It is identified by lab tests that show low testosterone accompanied by low to normal FSH and LH levels.
The depletion of the ovarian reserve causes an increase in circulating follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels because there are fewer oocytes and follicles responding to these hormones and producing estrogen. [citation needed] The transition has a variable degree of effects. [56]
Testing serum LH and FSH levels are often used to assess hypogonadism in women, particularly when menopause is believed to be happening. These levels change during a woman's normal menstrual cycle, so the history of having ceased menstruation coupled with high levels aids the diagnosis of being menopausal.
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